A developing company is having a meeting in their headquarters over their newly released product, the "i Babe", which is a life-sized, realistic replica of a nude woman which functions as an MP3 player.The boss (Richard Gere) listens to his various workers (Kate Bosworth, Aasif Mandvi and Jack Mc Brayer) argue over the placement of a fan that was built into the genital region of the i Babe, which is dismembering the penises of teenage boys who attempt to have sex with them.
This commercial was paid for by the "Society for the Prevention of Cruelty to Children Inside Machines".
Nathan (Jimmy Bennett) and Amanda (Chloë Grace Moretz) are watching television after school at Nathan's house as their first "middle school" date.
She cradles him and apologizes; covered and surrounded by his excrement on the road, she exclaims that it is the "most beautiful thing" she has ever seen and accepts his marriage proposal.
(In the end credits, Julie and Doug are mistakenly renamed Vanessa and Jason by Rocky Russo, Jeremy Sosenko, Steve Carr, Peter Farrelly, and Charles B. Neil (Kieran Culkin) is working a night shift at a local grocery store.
Wessler tries to calm Schraeder down with more story ideas to no avail, but Mone pulls out a gun and shoots Schraeder to death. They tell Baxter of a film that's so dangerous it will cause the annihilation of the world. They find the sketches starting from the 43rd search on the list of results. J.'s classmate Stevie Schraeder (Nate Hartley), film executive Griffin Schraeder's oldest son, hostage.
The segment ends with it being revealed that it is being shot by a camera crew as part of the movie, leading into the final segments. (Adam Cagley) make a video in the style of MTV's Jackass and upload it on You Tube where it instantly reaches over 1,000,000 views. Vrankovich warns them that if they find Movie 43, civilization will be left to ruins. They eventually find the real, the one and only Movie 43, which turns out to involve Baxter as a profane commando who leads a group of recruits to survive after the world has ended.
When he attempts to propose to her, she reveals to him that she is a coprophiliac, and asks him to defecate on her in the bedroom. Wanting foreplay, Julie is angered when Doug wants to finish, and she runs into the street.
Chasing after her, he is then hit by a car and graphically evacuates his bowels everywhere.
They believe the experience should be as awkward as possible, like "real high school".