Heigl first appeared in a national television spot for Cheerios cereal.
In 2003, Heigl appeared in three television movies, including the horror genre Evil Never Dies, a modern-day variation on the Frankenstein story co-starring Thomas Gibson, Love Comes Softly for Hallmark Entertainment as Marty Claridge, a young, pregnant newlywed traveling west and reprised her role in the sequel Love's Enduring Promise the next year.
Heigl played Isabella Linton in MTV's modern revamp of Emily Brontë's Wuthering Heights.
The main plotline has the train hijacked by mercenaries in Colorado, keeping her as a hostage.
Much of her work in the film was opposite Morris Chestnut, Sandra Taylor and Everett Mc Gill.
In 1986, her older brother Jason died of injuries suffered in a car accident, after being thrown from the back of a pickup truck while out for lunch with some of his high school classmates. Her brother's death led Heigl's parents to convert to The Church of Jesus Christ of Latter-day Saints and Heigl was reared in that faith (prior to that, her mother had been Lutheran and her father Catholic).
When Heigl was nine, an aunt visiting the family decided to take a number of photographs of her.
She made her film debut in That Night (1992) and later appeared in My Father the Hero (1994) as well as Under Siege 2: Dark Territory (1995).
Heigl played Izzie Stevens on the ABC medical drama Grey's Anatomy from 2005 to 2010, a role for which she won the Primetime Emmy Award for Outstanding Supporting Actress in a Drama Series in 2007.
In May 2006, Maxim awarded her #12 on their annual Hot 100List as well as voted the 19th "Sexiest Woman in the World" by readers of FHM magazine.
While Roswell was in production, Heigl worked on several films, including 100 Girls, an independent 2001 film, and Valentine, a horror film starring David Boreanaz and Denise Richards.
In 1995, she starred in the Steven Seagal action thriller Under Siege 2: Dark Territory.